CircRNA malignant fibrous histiocytoma amplified Sequence 1 (MFHAS1) reduced inflammatory responses in a Colitis Model via SIRT1/NF-κB

نویسندگان

چکیده

Ulcerative colitis (UC) is a chronic and non-specific inflammatory bowel disease (IBD). Its pathogenesis remains unclear, but its morbidity shows an increasing trend year by year. The of UC may be related to the genetic susceptibility, immune factor intestinal microflora. In last few years, number studies have examined relationship between expression levels peripheral CircRNA UC. We aimed evaluate efficacy MFHAS1 in possible mechanism. was reduced colitis, miR-486-5p also increased citrobacter rodentium-induced murine colitis. vitro model, over-expression responses, induced SIRT1 protein expression, suppressed NF-κB expression. However, model. inactivation anti-inflammation effects on responses Over-expression Our results demonstrated that reduces Colitis via SIRT1/NF-κB miR-486-5p.

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ژورنال

عنوان ژورنال: Food Science and Technology

سال: 2021

ISSN: ['2331-513X', '2331-5156']

DOI: https://doi.org/10.1590/fst.29220